Design, synthesis, and pharmacological evaluation of thapsigargin analogues for targeting apoptosis to prostatic cancer cells.

Jakobsen CM, Denmeade SR, Isaacs JT, Gady A, Olsen CE, Christensen SB

In vivo activity of a PSA-activated doxorubicin prodrug against PSA-producing human prostate cancer xenografts.

Khan SR, Denmeade SR

Delayed micromolar elevation in intracellular calcium precedes induction of apoptosis in thapsigargin-treated breast cancer cells.

Jackisch C, Hahm HA, Tombal B, McCloskey D, Butash K, Davidson NE, Denmeade SR

Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells.

Tombal B, Weeraratna AT, Denmeade SR, Isaacs JT